The New Orleans Saints provided one of the most lopsided and surprising results of Week 1 last season with a 38-3 win over the Green Bay Packers. The Packers will try to avoid another letdown to start this year when they take on the division-rival Minnesota Vikings. New Minnesota head coach Kevin O’Connell and offensive coordinator Wes Phillips come to the Vikings fresh off a Super Bowl win with the Los Angeles Rams, and the two-point line is one of the narrowest in the Week 1 NFL odds on Caesars Sportsbook. The Saints are 5.5-point road favorites in the NFL lines in their matchup against an Atlanta Falcons team reloaded with a host of young talent. Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has locked in five confident NFL best bets for Week 1. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 1 NFL picks at SportsLine.
Top Week 1 NFL picks
After simulating every game 10,000 times, the model is high on the Indianapolis Colts to cover as eight-point road favorites against the Houston Texans. Quarterback play has held the Colts back since Andrew Luck shocked the NFL world in 2019. Indianapolis hopes it has found its best solution yet in veteran Matt Ryan, whom it acquired from the Falcons in the offseason. Ryan should get a relatively light test in his debut against a Texans squad that ranked 27th in scoring defense last year.
The model projects an efficient 21-of-31 passing day for around 250 yards and two scores for Ryan. Running back Jonathan Taylor, meanwhile, easily clears 100 yards on the ground. The Colts score 29 points and cover in almost 60% of simulations, making them a strong choice for your Week 1 NFL parlays. See which other NFL parlay picks to make here.
How to make Week 1 NFL parlays
The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model’s NFL Week 1 best bets and parlay at SportsLine.
What are the model’s top Week 1 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 138-97 run on its top-rated picks, and find out.
