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    Home»Sports»Week 10 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay returns 25-1
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    Week 10 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay returns 25-1

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    The defending Super Bowl champion Los Angeles Rams could be without their star quarterback when they host the NFC West-rival Arizona Cardinals on Sunday. Matthew Stafford, who guided the Rams to the second Super Bowl championship in franchise history last season, was placed in concussion protocol on Tuesday after apparently suffering the injury in last week’s 16-13 loss at Tampa Bay. Los Angeles, which has lost four of its last five contests, would start John Wolford if Stafford is unable to play against Arizona. The Rams are 1-point favorites against the Cardinals in the latest Week 10 NFL odds at Caesars Sportsbook. Which Week 10 NFL lines should you target with your Week 10 NFL bets? Before you make any Week 10 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

    The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season.

    The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

    Now, the model has locked in five confident NFL best bets for Week 10. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 10 NFL picks at SportsLine.

    Top Week 10 NFL picks

    After simulating every game 10,000 times, the model is high on the Tennessee Titans (-3) to cover the spread against the Denver Broncos. Considering their uncertainty at the quarterback position, the Titans figure to rely heavily on Derrick Henry as they look to avoid back-to-back losses. Quarterback Ryan Tannehill could miss his third straight game with an ankle injury and rookie backup Malik Willis has completed only 11-of-26 attempts in his absence.

    Henry is a strong option on which to fall back, however, since he has taken over the NFL rushing lead with 870 yards over his first eight contests. The two-time league rushing leader has gained over 100 yards in five straight outings and will face a Denver defense that is 21st against the run with an average of 122.6 yards allowed. That is one reason the Titans are covering the spread in over 50% of simulations. See which other NFL parlay picks to make here.

    How to make Week 10 NFL parlays

    The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that has a chance to win outright. You can only see the model’s NFL Week 10 best bets and parlay at SportsLine. 

    What are the model’s top Week 10 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 10 NFL best bets from a model on a 151-108 run on its top-rated picks, and find out.



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